Vaccination provides protection against COVID-19, reducing the risk of severe illness and complications associated with the virus.
The study found that improved feature selection and collaboration could enhance the prediction of post-operative seizure freedom, leading to better surgical candidate selection.
The study found that 45% to 65% of patients achieved at least a 50% reduction in seizure frequency after VNS treatment. The clinical prediction model developed showed an area under the curve (AUC) of 0.7013 for the training sample, indicating a reasonable ability to predict VNS response.
The application of SPES resulted in power suppression in connected electrodes and a decrease in IED rates, suggesting that stimulation can effectively modulate neural activity and potentially reduce seizure frequency in focal epilepsy patients.
Outcomes showed that 68.2% of patients achieved seizure freedom (SF) at a median follow-up of 19.5 months, indicating a significant success rate for the procedure.
Ictal EEG changes were consistently detected in the CM and AN of the thalamus during neocortical seizures, suggesting the feasibility of using thalamic RNS for seizure control.
Identification of somatic genetic variants correlated with seizure onset and surgical outcomes, leading to refined histopathological classifications in 20.5% of cases. The study provides insights into the genetic landscape of epileptogenic lesions, potentially guiding future treatment strategies.
The study highlights that patients with an abnormal MRI have a significantly higher chance of achieving seizure freedom post-surgery (66.9%) compared to those with a normal MRI (45.5%).
The primary outcome is a reduction in parent-reported sleep problem scores, indicating improved sleep quality for children with Rolandic epilepsy. The intervention aims to enhance overall child well-being, learning, memory, and parental quality of life.
Over 50% of patients experience a reduction in seizures by 50% or more after one year, and over 70% are responders at three years.
Patients with better functional connectivity profiles as assessed by rs-fMRI had improved surgical outcomes, with some achieving Engel classification Ia (seizure-free) post-surgery.
The study found a highly significant reduction in IED frequency, with a decrease of 37% to 81% over the five days of stimulation, demonstrating the effectiveness of the personalized mc-tDCS in reducing epileptic activity.
The study demonstrated a one-year seizure freedom rate of 73% among resection patients, with no significant variation across different classifications of TLE. This indicates a high success rate for seizure control following the tailored surgical approach.
Identification of candidate disease-causing somatic variations in 56% of patients, contributing to the understanding of the genetic basis of epilepsy-associated lesions and potential new therapeutic targets.
The study found that patients with specific seizure onset patterns (SOPs) such as low voltage fast activity had a significantly higher probability of achieving seizure freedom (46%) compared to those with other patterns (0%).
The study found that elevated thalamic spikes and fast ripples during sleep were associated with unfavorable surgical outcomes, while lower rates of these activities during rest correlated with better outcomes. Enhanced thalamo-cortical connectivity during sleep was also linked to poor surgical prognosis, suggesting that thalamic activity can inform treatment decisions.
Patients with gain-of-function mutations in early-onset epilepsies responded well to sodium channel blockers, with phenytoin being the most commonly reported effective treatment.
The survey indicated that sodium channel blockers provided the best subjective seizure control and improved quality of life for patients. However, the high proportion of patients who previously tried and stopped ASMs highlights a significant unmet treatment need.
Functional analysis revealed gain-of-function in severe epilepsy phenotypes and loss-of-function in milder phenotypes, indicating a potential for precision medicine based on genotype-phenotype correlations.
Clonazepam, clobazam, topiramate, and levetiracetam were found to significantly reduce seizure frequency and/or maintain seizure freedom in patients with early-onset seizures and epileptic spasms.
Positive outcomes include a 63.7% rate of seizure remission within one year of treatment initiation. Early seizure control is crucial for preventing further disruptions to seizure-related networks and improving long-term prognosis.
The study found that early intervention with specific anti-seizure medications led to reduced seizure frequency, and individuals with neonatal seizures followed by seizure offset by 12 months had more predictable seizure trajectories.
The study found that seizure freedom rates varied significantly with FCD location, with rates around 30% in visual, motor, and premotor areas, and up to 75% in superior temporal and frontal gyri. The predictive model for postsurgical seizure freedom had a positive predictive value of 70% and a negative predictive value of 61%.
On-scalp MEG detected IEDs in all children with higher amplitudes (2.3-4.8 times) and SNR (27-60% higher) compared to cryogenic MEG, indicating improved diagnostic capabilities.
The study successfully identified and validated mosaic variants in DNA extracted from trace brain tissue on sEEG electrodes in patients with DRE. This approach demonstrated a relationship between genetic abnormalities and seizure activity, suggesting its potential for advancing precision medicine in epilepsy treatment.
Significant reduction in the amplitude of evoked potentials from remote regions after high-frequency stimulation, indicating changes in effective connectivity that accumulate over time.
The adaptive trial design resulted in a modest increase in statistical power to identify effective treatments, with only 8% of participants remaining in the placebo group throughout the trial. This approach aims to maximize the time spent in effective treatment groups, thereby improving overall treatment outcomes.
The study found that utilizing fast ripple metrics can accurately predict seizure freedom post-resection. In patients who were not seizure-free, adjusting the resection boundaries based on FR metrics led to improved outcomes, with some patients achieving virtual seizure freedom. Additionally, targeting RNS stimulation to high-rate FR sites showed potential for enhancing seizure outcomes.
The study found that background EEG features tracked multidien cycles in dIEA, suggesting a relationship between brain state and seizure risk. Neurostimulation was shown to suppress the coupling between EEG features and dIEA, potentially aiding in seizure management.
The interictal EEG biomarkers correctly classified mesial temporal SOZ electrodes with 87% specificity and 80% positive predictive value, and predicted patient outcomes after surgical resection with 91% specificity and 87% positive predictive value.
Children with neonatal seizure onset and recurrent seizures generally respond well to treatment. Early intervention and therapy can lead to age-appropriate participation in life despite the challenges posed by PIS.
The study aimed to provide initial evidence on the potential of biperiden to reduce the incidence of post-traumatic epilepsy, suggesting that it may influence the later development of seizures in patients with TBI.
Despite the lack of identifiable genetic causes, the study highlights a heterogeneous range of treatment strategies and emphasizes the need for further research into novel diagnostic and treatment approaches for FIRES.
Post-treatment, 75% of subjects exhibited increased network small-worldness, indicating improved brain network organization. Changes were most notable in superior frontoparietal and inferior frontal and temporal regions, which are associated with cognitive functions.
The study found that 53% of patients who were seizure-free for at least one year had documented discussions about ASM discontinuation, and 21% planned to discontinue at least one ASM. For those seizure-free for at least two years, these figures increased to 65% and 26%, respectively.
The study found that epilepsy is frequent and polymorphic in ASA, with early-onset epilepsy and electroencephalographic background asymmetry being significant predictors of pharmacoresistance. Patients with epilepsy also exhibited higher rates of neurodevelopmental complications, including speech delays and autism spectrum disorders.
The study found that ECoG and SEEG provide different insights into brain connectivity, which can lead to improved surgical outcomes by better targeting the epileptogenic zone and potentially increasing rates of post-operative seizure freedom.
The study emphasizes the importance of managing epilepsy in pregnancy, as poor seizure control can lead to maternal death. It highlights that lamotrigine may have a more favorable safety profile compared to valproic acid for pregnancy-related ADRs, suggesting that careful selection of AEDs can mitigate risks to both mother and child.